Journal Publications


  • Zaslavsky J, Allen C. A dataset of formulation compositions for self-emulsifying drug delivery systems. Scientific Data 10, 914, 2023. Link
  • Wang X, Regenold M, Dunne M, Bannigan P, Allen C. Data demonstrating the in vivo anti-tumor efficacy of thermosensitive liposome formulations of a drug combination in pre-clinical models of breast cancer. Data in Brief, 2023. Link
  • Allen, C. Lessons learned from a decade as an Editor of Scientific Journals. Journal of Controlled Release, 2023, 353:1171. PubMed Link.
  • Bao Z, Yung F, Hickman R, Aspuru-Guzik A, Bannigan P, Allen C. Data-driven development of an Oral Lipid-based Nanoparticle Formulation of a Hydrophobic Drug. Drug Delivery and Translational Research, 2023. Link.
  • Hickman RJ, Sim M, Pablo-Garc S, Woolhouse I, Hao H, Bao Z, Bannigan P, Allen C, Aldeghi M, Aspuru-Guzik A. Atlas: A Brain for Self-driving Laboratories. ChemRxiv, 2023. Link.
  • Bao Z, Bufton J, Hickman RJ, Aspuru-Guzik A, Bannigan P, Allen C. Revolutionizing Drug Formulation Development: The Increasing Impact of Machine Learning. Advanced Drug Delivery Reviews, 2023. Link
  • Hickman RJ, Bannigan P, Bao Z, Aspuru-Guzik A, Allen C. Self-driving laboratories: A paradigm shift in nanomedicine development. Matter, 2023 6(4): 1071-1081. PubMed Link.
  • Bao Z, Jung S, Bufton J, Bannigan P, DJ Aguiar, Allen C. Data evaluating triamcinolone acetonide and triamcinolone hexacetonide loaded poly (δ-valerolactone-co-allyl-δ-valerolactone) microparticles. Data in Brief, 2023, 48: 109032.  PubMed Link.
  • Regenold M, Wang X, Kaneko K, Bannigan P, Allen C. Harnessing immunotherapy to enhance the systemic anti-tumor effects of thermosensitive liposomes. Drug Delivery and Translational Research 13 (4), 1059-1073. PubMed Link.
  • Wang L, Evans JC, Ahmed L, Allen C. Folate receptor targeted nanoparticles containing niraparib and doxorubicin as a potential candidate for the treatment of high grade serous ovarian cancer. Scientific Reports 13 (1), 3226. PubMed Link.
  • Regenold M, Kaneko K, Wang X, Peng HB, Evans JC, Bannigan P, Allen C. Triggered release from thermosensitive liposomes improves tumor targeting of vinorelbine. Journal of Controlled Release 354, 19-33. PubMed Link.
  • Zaslavsky J, Bannigan P, Allen C. Re-envisioning the design of nanomedicines: Harnessing automation and artificial intelligence. Expert Opinion on Drug Delivery. 2023. PubMed Link.
  • Bannigan P, Bao Z, Hickman RJ, Aldeghi M, Häse F, Aspuru-Guzik A, Allen C. Machine learning models to accelerate the design of polymeric long-acting injectables. Nature Communications 14 (1), 35. PubMed Link.


  • Regenold M, Bannigan P, Evans JC, Waspe A, Temple MJ, Allen C. Turning down the heat: The case for mild hyperthermia and thermosensitive liposomes. Nanomedicine: Nanotechnology, Biology and Medicine 40, 102484. PubMed Link.
  • Bannigan P, Evans JC, Allen C. Shifting the paradigm on cannabis safety. Cannabis and cannabinoid research 7 (1), 3-10. PubMed Link.
  • Kok LY, Bannigan P,  Sanaee F, Evans JC, Dunne M, Regenold M, Ahmed L, Dubins D, Allen C. Development and pharmacokinetic evaluation of a self-nanoemulsifying drug delivery system for the oral delivery of cannabidiol. European Journal of Pharmaceutical Sciences 168, 106058. PubMed Link.


  • Bannigan P., Aldeghi M., Bao Z., Häse F., Aspuru-Guzik A., Allen C., Machine learning directed drug formulation development. Advanced Drug Delivery Reviews 2021, 175: 113806. PubMed Link.
  • Epp-Ducharme B., Dunne M., Fan L., Evans J.C., Ahmed L., Bannigan P., Allen C., Heat-activated nanomedicine formulation improves the anti-cancer potential of the HSP90 inhibitor Luminespib. Nature Scientific Reports 2021, 11: 11103. OpenAccess Link.
  • Bufton, J., Jung S., Evans C.J., Bao Z., Aguiar D., Allen C., Cross-linked valerolactone copolymer implants with tailorable biodegradation, loading and in vitro release of paclitaxel. European Journal of Pharmaceutical Sciences 2021, In Press. PubMed Link.
  • Bao Z., Jung S., Bufton J., Evans J.C., Aguiar D.J., Allen C., Poly(valerolactone-co-allyl-valerolactone) Cross-linked Microparticles: Formulation, Characterization and Biocompatibility. Journal of Pharmaceutical Sciences 2021, 162, 105808. PubMed Link.


  • Regenold M., Steigenberger J., Siniscalchi E., Dunne M., Casettari L., Heerklotz H., Allen C., Determining critical parameters that influence in vitro performance characteristics of a thermosensitive liposome formulation of vinorelbine. Journal of Controlled Release 2020, 328, 551-561. PubMed Link.
  • Dunne M., Regenold M., Allen C., Hyperthermia can alter tumor physiology and improve chemo- and radiotherapy efficacy. Advanced Drug Delivery Reviews, 2020, 163, 98-124. PubMed Link.
  • Dunne M., Evans J.C., Dewhirst M.W., Allen C., The integration of hyperthermia in drug delivery, Advanced Drug Delivery Reviews, 2020, 163, 1-2. PubMed Link.
  • Yu Q., Roberts M.G. Houdaihed L., Liu Y., Ho K, Walker G., Allen C., Reilly R.M., Manners I., Winnik M.A., Investigating the influence of block copolymer micelle length on cellular uptake and penetration in a multicellular tumor spheroid model. Nanoscale, 2020, 13(1), 280-291. PubMed Link.
  • Allen C., Evans J.,‘Hip to be square’: Designing PLGA formulations for the future, Journal of Controlled Release 2020, 319, 487-488. PubMed Link.
  • Shen Y.T., Asthana R., Peeters C., Allen C., DeAngelis C., Piquette-Miller M., Potential Limitations of Bioluminescent Xenograft Mouse Models: A Systematic Review, Journal of Pharmacy & Pharmaceutical Sciences, 2020, 23, 177 – 199. PubMed Link.
  • Roberts M.G., Yu Q., Keunen R., Liu J., Wong E.C.N., Rastogi C.K., Reilly R. M., Allen C., Winnik M.A., Functionalization of Cellulose Nanocrystals with POEGMA-Copolymers via Copper Catalyzed Azide-Alkyne Cycloaddition for Potential Drug Delivery Applications, Biomacromolecules 2020, 21, 2014-2023. ACS Link.
  • Allen C., Dunne M., The power of integrating imaging throughout the drug development process, Journal of Controlled Release 2020, 317, 386-388. PubMed Link.
  • Muhanna N., Eu D., Chan H.H.L., Daly M., Douglas C.M., Townson J.L., Zheng J., Allen C., Jaffray D.A., Irish J.C. Assessment of a Liposomal CT/Optical Agent for Image-Guided Head and Neck Surgery. Nanomedicine: Nanotechnology, Biology and Medicine,  2020, 32, 102327. ScienceDirect Link.
  • Houdaihed L., Evans J.C., Allen C., Dual-Targeted Delivery of Nanoparticles Encapsulating Paclitaxel and Everolimus: A Novel Strategy to Overcome Breast Cancer Receptor Heterogeneity. Pharmaceutical Research, 2020, 37, 39. PubMed Link.
  • Santos M.A., Wu S.K., Regenold M., Allen C., Goertz D.E., Hynynen K., Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs. Science Advances, 2020, 6, eaba5684. AAAS Link.
  • Bannigan P., Evans J., Allen C., Shifting the Paradigm on Cannabis Safety, Cannabis and Cannabinoid Research, 2020, In Press. Liebertpub Link.


  • Allen C., The Question of Toxicity of Nanomaterials and Nanoparticles. Journal of Controlled Release, 2019, 304, 288. PubMed Link.
  • Allen C., Park K., What do we do next? Journal of Controlled Release, 2019, 302, 203. PubMed Link.
  • Houdaihed L., Evans J.C., Allen C., In vivo Evaluation of Dual-Targeted Nanoparticles Encapsulating Paclitaxel and Everolimus. Cancers, 2019, 11, 1-16. PubMed link.
  • Dunne M., Epp-Ducharme B., Sofias A.M., Regenold M., Allen C., Heat-activated drug delivery increases tumor accumulation of synergistic chemotherapies. Journal of Controlled Release, 2019, 308, 197 – 208. PubMed Link.
  • Siepmann J., Faham A., Clas S-D., Boyd B.J., Jannin V., Bernkop-Schnurch A., Zhao H., Lecommandoux S., Evans J.C., Allen C., Merkel O.M., Costabile G., Alexander M.R., Wildman R.D., Roberts C.J., Leroux J.C., Lipids and Polymers in Pharmaceutial Technology: Lifelong Companions. International Journal of Pharmaceutics, 2019, 558, 128-142. PubMed Link.
  • Allen C., Can we overcome the most significant barrier to treatment of neurodegenerative diseases? Journal of Controlled Release, 2019, 303, 319-320. PubMed Link.
  • Yu Q., Roberts M.G., Pearce S., Oliver A.M., Zhou H., Allen C., Manner I., Winnik M.A. Rodlike Block Copolymer Micelles of Controlled Length in Water Designed for Biomedical Applications. Macromolecules, 2019, 52, 5231-5244. ACS Link.
  • Allen C., Bannigan P., Does artificial intelligence have the potential to transform drug formulation development? Journal of Controlled Release, 2019, 311-312, 326-327. PubMed Link.
  • Allen C., Nanomedicine Researchers: Slow Down to Speed Up, Journal of Controlled Release, 2019, 315, 214-215. ScienceDirect Link.
  • Shen Y.T., Wang L., Evans J.C., Allen C., Piquette-Miller M., Development of a Bioluminescent BRCA1-Deficient Xenograft Model of Disseminated, High-Grade Serous Ovarian Cancer, International Journal of Molecular Sciences, 2019, 20(10), 2498. PubMed Link.


  • Dunne M., Dou YN., Drake DM., Spence T., Gontijo SML., Wells PG., Allen C., Hyperthermia-Mediated Drug Delivery Induces Biological Effects at the Tumor and Molecular Levels that Improve Cisplatin Efficacy in Triple Negative Breast Cancer.  Journal of Controlled Release, 2018, 282: 35-45. PubMed Link.
  • Alhamami M., Cheng W., Lyu Y., Allen C., Zhang X., Cheng H. Manganese-Porphyrin-Enhanced MRI for the Detection of Cancer Cells: A Quantitative In Vitro Investigation with Multiple Clinical Subtypes of Breast Cancer. PLoS ONE, 2018, 13(5): e0196998. PubMed Link.
  • Le Devedec F., Boucher H., Dubins DN, Allen C., Factors Controlling Drug Release in Cross-linked Poly(valerolactone) Based Matrices. Molecular Pharmaceutics, 2018, 15(4): 1565-1577. PubMed Link.
  • Shen Yen Ting, Evans James C., Zafarana Gaetano, Allen C., Piquette-Miller Micheline BRCA Status Does Not Predict Synergism of a Carboplatin and Olaparib Combination in High-Grade Serous Ovarian Cancer Cell Lines. Molecular Pharmaceutics, 2018, 15, 2742-2753.​ ACS Link.
  • Houdaihed L. Evans J., Allen C., Co-Delivery of Paclitaxel and Everolimus at the Optimal Synergistic Ratio: a Promising Solution for the Treatment of Breast Cancer, Molecular Pharmaceutics, 2018, 15, 9, 3672-3681. PubMed Link.
  • Stapleton S., Milosevic M., Vedadi A., Dunne M., Tran C.W., McKee T.D. Ohashi P., Allen C., Jaffray D.A., Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intra-Tumoral Fluid Dynamics. ACS Nano, 2018, 12, 7583-7600. PubMed Link.


  • Eetezadi S., Evans J., Shen Y., De Souza R., Piquette-Miller M., Allen C. Ratio-Dependent Synergism of a Doxorubicin and Olaparib Combination in 2D and Spheroid Models of Ovarian Cancer. Molecular Pharmaceutics. 2017, 15(2) 472-485. PubMed link
  • Dunne M., Hynynen K., Allen C. Thermosensitive nanomedicines Could Revolutionize Thermal Therapy in Oncology. Nanotoday. 2017, 16: 9-13​. ScienceDirect link
  • ​Houdaihed L., Evans JC, Allen C. Overcoming the Road Blocks: Advancement of Block Copolymer Micelles for Cancer Therapy in the Clinic. Molecular Pharmaceutics. 2017, 14(8):2503-2517. PubMed link
  • Tan Q., Joshua A., Wang M., Bristow R., Wouters B., Allen C., Tannock I. Up-Regulation of Autophagy is a Mechanism of Resistance to Chemotherapy and Can be Inhibited by Pantoprazole to Increase Drug Sensitivity. Cancer Chemotherapy and Pharmacology. 2017, 79(5):959-969. PubMed link
  • Sofias A.M., Dunne M., Storm G., Allen C. The Battle of “Nano” Paclitaxel. Advanced Drug Delivery Reviews. 2017, 122: 20-30. PubMed link
  • Dou Y., Hynynen K., Allen C. To Heat or Not to Heat: Challenges with Clinical Translation of Thermosensitive Liposomes. Journal of Controlled Release. 2017, 249: 63-73. PubMed link
  • Allen C., Her S., Jaffray D.A. Radiotherapy for Cancer: Present and Future. Advanced Drug Delivery Reviews. 2017, 109: 1-2. PubMed link
  • Her S., Jaffray DA., Allen C. Gold Nanoparticles for Applications In Cancer Radiotherapy: Mechanisms and Recent Advancements. Advanced Drug Delivery Reviews. 2017, 109: 84-101. PubMed link
  • Le Devedec F., Her S., Vogtt K., Won A., Li X., Beaucage G., Yip C. Allen C. Drug Governs Morphology of Polyalkylated Block Copolymer Aggregates. Nanoscale. 2017, 9(7): 2417-2423. (Selected for front cover of issue). PubMed link
  • Dou Y.N., Chaudary N., Chang M.C., Dunne M., Huang H., Jaffray D.A., Milosevic M., Allen C., Tumor Microenvironment Determines Response to a Heat-Activated Thermosensitive Liposome Formulation of Cisplatin in Cervical Carcinoma. Journal of Controlled Release. 2017 262, 182-191. PubMed link
  • Cui L., Her S., Borst G.R., Bristow R. G., Jaffray D.A., Allen C., Radiosensitization by Gold Nanoparticles: Will They Ever Make it to the Clinic? Radiotherapy and Oncology. 2017, 124, 344 – 356. PubMed link
  • Cui L., Her S., Dunne M., Borst G., De Souza R., Bristow R., Jaffray D., Allen C. Significant Radiation Enhancement Effects by Gold Nanoparticles in Combination with Cisplatin in Triple Negative Breast Cancer Cells and Tumor Xenografts. Radiation Research. 2017, 187(2): 147-160. PubMed link


  • Allen C. Why I’m Holding onto Hope for Nano in Oncology. Mol. Pharmaceutics. 2016, 13 (8): 2603–2604. PubMed link
  • Guo M., Her S., Keunen R., Zhang S., Allen C., Winnik M. Functionalization of Cellulose Nanocrystals with PEG-Metal-Chelating Block Copolymers via Controlled Conjugation in Aqueous Media. ACS Omega. 2016, 1 (1): 93–107. ACS link
  • Ekdawi S., Jaffray D., Allen C. Nanomedicine and Tumor Heterogeneity: Concept and Complex Reality. Nanotoday. 2016, 11 (4): 402-414. ScienceDirect link
  • Dou YN., Dunne M., Huang H., Mckee T., Chang MC., Jaffray D., Allen C. Thermosensitive Liposomal Cisplatin in Combination with Local Hyperthermia Results in Tumor Growth Delay and Changes in Tumor Microenvironment in Xenograft Models of Lung Carcinoma. Journal of Drug Targeting. 2016, 16: 1-13. PubMed link
  • Le Devedec F., Houdaihed L., Allen C. Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π- π Stacking Interactions. JOVE. 2016, 10 (116), doi: 10.3791/54422.
  • Her S., Cui L., Bristow RG., Allen C. Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer. Radiation Research. 2016, 185(5):549-62. PubMed link
  • Stapleton S., Mirmilshteyn D., Zheng J., Allen C. Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors. JOVE. 2016,  (114), doi: 10.3791/54226. PubMed link 
  • Le Devedec F., Won A., Oake J., Houdaihed L., Bohne C.,Yip CM., Allen C. Postalkylation Of A Common Mpeg‑B‑PAGE Precursor To Produce Tunable Morphologies Of Spheres, Filomicelles, Disks, And Polymersomes. ACS Macro Letters. 2016, 5: 128 – 133. ACS link


  • Spence T., De Souza R., Dou Y., Stapleton S., Reilly R.M., Allen C. Integration Of Imaging Into Clinical Practice To Assess The Delivery And Performance Of Macromolecular And Nanotechnology-Based Oncology Therapies. Journal of Controlled Release. 2015, 219: 295 – 312. PubMed link
  • De Souza R., Spence T., Dou Y., Allen C. Preclinical Imaging And Translational Oncology Metastatic Animal Models In The Development And Assessment Of Novel Nanotechnologies And Macromolecular Agents For Accelerated Clinical Implementation. Journal of Controlled Release. 2015, 219: 313 – 330. PubMed link
  • Eetezadi S., De Souza R., Vythilingam M., Lessa Cataldi R., Allen C. Effects of Doxorubicin Delivery Systems and Mild Hyperthermia on Tissue Penetration in 3D Cell Culture Models of Ovarian Cancer Residual Disease. Molecular Pharmaceutics. 2015, 12, 3973 – 3985. PubMed link
  • Dou Y., Weersink R., Zheng J., Jaffray D.A., Allen C. Custom-Designed Laser-Based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance. JOVE. 2015, 106, e53055.
  • Zheng J., Muhanna N., De Souza R., Wada., Chan H., Akens M., Anayama T., Yasufuku K., Serra S., Irish J., Allen C., Jaffray D. A Multimodal Nano Agent For Image-Guided Cancer Surgery.  Biomaterials. 2015, 67: 160–168. ScienceDirect link
  • Stapleton S., Milosevic M., Tannock I., Allen C., Jaffray D. The Intra-Tumoral Relationship Between Microcirculation, Interstitial Fluid Pressure And Liposome Accumulation. Journal of Controlled Release. 2015, 211:163-179. PubMed link
  • Merian J., De Souza R., Dou Y., Ekdawi S.N., Ravenelle F., Allen C. Development Of A Liposome Formulation For Improved Biodistribution And Tumor Accumulation Of Pentamidine For Oncology Applications. International Journal of Pharmaceutics. 2015, 488:154-164. PubMed link
  • Ekdawi S.N., Stewart J.M.P., Dunne M., Stapleton S., Mitsakakis N., Dou Y.N., Jaffray D.A., Allen C. Spatial And Temporal Mapping Of Heterogeneity In Liposome Uptake And Microvascular Distribution In An Orthotopic Tumor Xenograft Model. Journal of Controlled Release. 2015, 207:101-111. PubMed link
  • Banerjee N., Wu R.T., Chio J., Kelly R., Stephenson K.A., Forbes J., Allen C., Valliant J.F., Bendayan R. 125I-Labelled 2-Iodoestrone-3-Sulfate: Synthesis, Characterization And OATP Mediated Transport Studies In Hormone Dependent And Independent Breast Cancer Cells. Nuclear Medicine and Biology. 2015, 42:274-282. PubMed link​
  • Eetezadi S., Ekdawi S.N., Allen C. The Challenges Facing Block Copolymer Micelles for Cancer Therapy: In Vivo Barriers and Clinical Translation. Advanced Drug Delivery Reviews. 2015, 91: 7-22. PubMed link


  • Cui L., Tse K., Zahedi P., Harding S.M., Zafarana G., Jaffray D.A., Bristow R.G., Allen C.Hypoxia and Cellular Localization Influence the Radiosensitizing Effect of Gold Nanoparticles (AuNPs) in Breast Cancer Cells. Radiation Research. 2014, 182:475-488. PubMed link
  • Banerjee N., Miller N., Allen C., Bendayan R. Expression of Membrane Transporters and Metabolic Enzymes Involved in Estrone-3-Sulphate Disposition in Human Breast Tumour Tissues. Breast Cancer Research and Treatment. 2014, 145:647-61. PubMed link
  • Dou Y.N., Zheng J., Foltz W.D., Weersink R., Chaudary N., Jaffray D.A., Allen C. Heat-activated Thermosensitive Liposomal Cisplatin (HTLC) Results in Effective Growth Delay of Cervical Carcinoma in Mice. Journal of Controlled Release. 2014, 178:69-78. PubMed link
  • Mikhail A.S., Eetezadi S., Ekdawi S.N., Stewart J., Allen C. Image-Based Analysis of the Size- and Time-Dependent Penetration of Polymeric Micelles in Multicellular Tumor Spheroids and Tumor Xenografts. International Journal of Pharmaceutics. 2014, 464:168-177. PubMed link
  • Lu C., Zahedi P., Forman A., Allen C. Multi-arm PEG/Silica Hydrogel for Sustained Ocular Drug Delivery. Journal of Pharmaceutical Sciences. 2014, 103:216-226. PubMed link


  • Stapleton S., Milosevic M., Allen C., Zheng J., Dunne M., Yeung I., Jaffray D.A. A Mathematical Model of the Enhanced Permeability and Retention Effect for Liposome Transport in Solid Tumors. PLoS ONE. 2013, 8(12): e81157. PubMed link
  • Fardell J., Zhang J., De Souza R., Vardy J., Johnston I., Henderson J., Allen C., Piquette-Miller M. The Impact of Sustained and Intermittent Docetaxel Chemotherapy Regimens Impact Cognition and Neural Morphology in Healthy Mice. Psychopharmacology. 2014, 231:841–852. PubMed link
  • Hoang B., Ekdawi S.N., Reilly R.M., Allen C. Active Targeting of Block Copolymer Micelles with Trastuzumab Fab Fragments and Nuclear Localization Signal Leads to Increased Tumor Uptake and Nuclear Localization in HER2-Overexpressing Xenografts.Molecular Pharmaceutics. 2013, 10:4229-4241. PubMed link
  • Stapleton S., Allen C., Pintillie M., Jaffray D.A. Tumor Perfusion Imaging Predicts the Intra-Tumoral Accumulation of Liposomes. Journal of Controlled Release. 2013, 172:351-357. PubMed link
  • Zhidkov N., De Souza R., Ghassemi A.H., Allen C., Piquette-Miller M. Continuous Intraperitoneal Carboplatin Delivery for the Treatment of Late-Stage Ovarian Cancer.Molecular Pharmaceutics. 2013, 10:3315-3322. PubMed link
  • Grant J., Zahedi P., Tsallas A., Allen C. Thermosensitive Depot-Forming Injectable Phosphatidylcholine Blends Tailored for Localized Drug Delivery. Journal of Pharmaceutical Sciences. 2013, 102:3623-3631. PubMed link
  • Anayama T., Nakajima T., Dunne M., Zheng J., Allen C., Driscoll B., Vines D., Keshavjee S., Jaffray D., Yasufuku K. A Novel Minimally Invasive Technique to Create a Rabbit VX2 Lung Tumor Model for Nano-Sized Image Contrast and Interventional Studies. PLoS ONE. 2013, 8(6): e67355. PubMed link
  • Banerjee N., Fonge H., Mikhail A., Reilly R.M., Bendayan R., Allen C. Estrone-3-Sulphate, a Potential Novel Ligand for Targeting Breast Cancers. PLoS ONE. 2013, 8(5): e64069. PubMed link
  • Mikhail A.S., Eetezadi S., Allen C. Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines in Vitro: A Comparison of Docetaxel-loaded Block Copolymer Micelles and Taxotere®. PLoS ONE.2013, 8(4): e62630. PubMed link
  • Huang H., Dunne M., Lo J., Jaffray D.A., Allen C. Comparison of Computed Tomography– and Optical Image–Based Assessment of Liposome Distribution. Molecular Imaging. 2013, 12:148-60. PubMed link
  • Lu C., Yoganathan R., Kociolek M., Allen C. Hydrogel Containing Silica Shell Cross-linked Micelles for Ocular Drug Delivery. Journal of Pharmaceutical Sciences. 2013, 102:627-637. PubMed link
  • Cui L., Zahedi P., Saraceno J., Bristow R., Jaffray D., Allen C. Neoplastic Cell Response to Tiopronin-coated Gold Nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine. 2013, 9:264-273. PubMed link


  • Banerjee N., Allen C., Bendayan R., Differential Role of OATPs in Estrone-3-sulphate Uptake by Breast Epithelial Cells and Breast Cancer Cells. Journal of Pharmacology and Experimental Therapeutics. 2012, 342:510-519. PubMed link
  • Hoang B., Reilly R.M., Allen C. Block Copolymer Micelles Target Auger Electron Radiotherapy to the Nucleus of HER2-Positive Breast Cancer Cells. Biomacromolecules. 2012, 13:455-465. PubMed link
  • Zahedi P., Yoganathan R. Piquette-Miller M., Allen C. Recent Advances in Drug Delivery Strategies for Treatment of Ovarian Cancer. Expert Opinion on Drug Delivery. 2012, 9:567-583. PubMed link
  • Zahedi P., Stewart J., De Souza R., Piquette-Miller M., Allen C. An Injectable Depot System for Sustained Intraperitoneal Chemotherapy of Ovarian Cancer Results in Favorable Drug Distribution at the Whole Body, Peritoneal and Intratumoral Levels.Journal of Controlled Release. 2012, 158:379-385. PubMed link
  • Fonge H., Huang H., Scollard D., Reilly R.M., Allen C. Influence of Formulation Variables on the Biodistribution of Multifunctional Block Copolymer Micelles. Journal of Controlled Release. 2012, 157:366-374. PubMed link
  • Huynh L., Neale C., Pomès R., Allen C. Computational Approaches to the Rational Design of Nanoemulsions, Polymeric Micelles, and Dendrimers for Drug Delivery. Nanomedicine: Nanotechnology, Biology, and Medicine. 2012, 8:20-36. PubMed link
  • Lu C., Mikhail A.S., Wang X., Brook M.A., Allen C. Hydrogels Containing Core Cross-Llinked Block Copolymer Micelles. Journal of Biomaterials Science – Polymer Edition.2012, 23:1069-1090. PubMed link


  • Dunne M., Zheng J., Rosenblat J., Jaffray D.A., Allen C. APN/CD13-Targeting as a Strategy to Alter the Tumor Accumulation of Liposomes. Journal of Controlled Release. 2011, 154:298-305. PubMed link
  • De Souza R., Zahedi P., Badame R., Allen C., Piquette-Miller M. Chemotherapy Dosing Schedule Influences Drug Resistance Development in Ovarian Cancer. Molecular Cancer Therapeutics. 2011, 10:1289-1299. PubMed link
  • Zahedi P., De Souza R., Piquette-Miller M., Allen C. Docetaxel Distribution Following Intraperitoneal Administration in Mice. Journal of Pharmacy and Pharmaceutical Sciences. 2011, 14:90-99. PubMed link
  • Zahedi P., De Souza R., Huynh L., Piquette-Miller M., Allen C. Combination Drug Delivery Strategy for the Treatment of Multidrug Resistant Ovarian Cancer. Molecular Pharmaceutics. 2011, 8:260–269. PubMed link


  • Huyhn L., Neale C., Pomes R., Allen C. Systematic Design of Unimolecular Star Copolymer Micelles Using Molecular Dynamics Simulations. Soft Matter. 2010, 6:5491-5501. PubMed link
  • Lee H., Hoang B., Fonge F., Reilly R.M., Allen C. In Vivo Distribution of Polymeric Nanoparticles at the Whole Body, Tumor, and Cellular Levels. Pharmaceutical Research. 2010, 27:2343-2355. PubMed link
  • Lee H., Fonge H., Hoang B., Reilly R.M., Allen C. The Effects of Particle Size and Molecular Targeting on the Intratumoral and Subcellular Distribution of Polymeric Nanoparticles. Molecular Pharmaceutics. 2010, 7:1195–1208. PubMed link
  • De Souza R., Zahedi P., Allen C., Piquette-Miller M. Polymeric Drug Delivery Systems for Localized Chemotherapy. Drug Delivery. 2010, 99:2664-2671. PubMed link
  • Zheng J., Allen C., Serra S., Vines D., Charron M., Jaffray D.A. Liposome Contrast Agent for CT-based Detection and Localization of Neoplastic and Inflammatory Lesions in Rabbits: Validation with FDG-PET and Histology. Contrast Media and Molecular Imaging.2010, 5:147–154. PubMed link
  • Chithrani B.D., Jelveh S., Jalali F., van Prooijen M., Allen C., Bristow R., Hill R.P., Jaffray D.A. Gold Nanoparticles as a Radiation Sensitizer in Cancer Therapy. Radiation Research. 2010, 173:719-28. PubMed link
  • Mikhail A.S., Allen C. Polyethylene Glycol-b-Polycaprolactone Micelles Containing Chemically Conjugated and Physically Entrapped Docetaxel: Synthesis, Characterization and the Influence of the Drug on Micelle Morphology. Biomacromolecules. 2010, 11:1273–1280. PubMed link
  • De Souza R., Zahedi P., Moriyama E.H., Allen C., Wilson B.C., Piquette-Miller M. Continuous Docetaxel Chemotherapy Improves Therapeutic Efficacy in Murine Models of Ovarian Cancer. Molecular Cancer Therapeutics. 2010, 9:1820-1830. PubMed link
  • Fonge H., Lee H., Reilly R.M., Allen C. Multifunctional Block Copolymer Micelles for the Delivery of 111In to EGFR-Positive Breast Cancer Cells for Targeted Auger Electron Radiotherapy. Molecular Pharmaceutics. 2010, 7:177–186. PubMed link
  • Chithrani B.D., Dunne M., Allen C., Jaffray D.A. Cellular Uptake and Transport of Gold Nanoparticles Incorporated in a Liposomal Carrier. Nanomedicine: Nanotechnology, Biology and Medicine. 2010, 6:161-169. PubMed link


  • Huynh L., Leroux J.C., Allen C. Enhancement of Docetaxel Solubility via Conjugation of Formulation-Compatible Moeities. Organic and Biomolecular Chemistry. 2009, 7:3437-3446. PubMed link
  • Mikhail A.S., Allen C. Block Copolymer Micelles for Delivery of Cancer Therapy: Transport at the Whole Body, Tissue and Cellular Levels. Journal of Controlled Release. 2009, 138:214-223. PubMed link
  • Zahedi P., De Souza R., Piquette-Miller M., Allen C. Chitosan-Phospholipid Blend for Sustained and Localized Delivery of Docetaxel to the Peritoneal Cavity. International Journal of Pharmaceutics. 2009, 377:76–84. PubMed link
  • Chithrani D., Stewart J., Allen C., Jaffray D.A. Intracellular Uptake, Transport, and Processing of Nanostructures in Cancer Cells. Nanomedicine: Nanotechnology, Biology, and Medicine. 2009, 5:118-27. PubMed link
  • De Souza R., Zahedi P., Allen C., Piquette-Miller M. Biocompatibility of Injectable Chitosan-Phospholipid Implant Systems. Biomaterials. 2009, 30:3818-3824. PubMed link
  • Zheng J., Jaffray D.A., Allen C. Quantitative CT Imaging of the Spatial and Temporal Distribution of Liposomes in a Rabbit Tumor Model. Molecular Pharmaceutics. 2009, 6:571–580. PubMed link
  • Hoang B., Lee H., Reilly R.M., Allen C. Non-Invasive Monitoring of the Fate of 111In-Labeled Block Copolymer Micelles by High Resolution and High Sensitivity MicroSPECT/CT Imaging. Molecular Pharmaceutics. 2009, 6:581–592. PubMed link
  • Perron M-È., Plourde F., Guérard S., Huynh L., Allen C., Leroux J.C. An Investigation on the use of Tributyrin Nanoemulsions for Docetaxel Delivery. Journal of Drug Delivery Science and Technology. 2009, 18:189-195. ScienceDirect link


  • Vassileva V., Moriyama E.H., De Souza R., Grant J., Allen C., Wilson B.C., Piquette-Miller M. Efficacy Assessment of Sustained Intraperitoneal Paclitaxel Therapy in a Murine Model of Ovarian Cancer Using Bioluminescent Imaging. British Journal of Cancer. 2008, 99:2037–2043. PubMed link
  • Grant J., Lee H., Liu R.C.W., Allen C. Intermolecular Interactions and Morphology of Aqueous Polymer/Surfactant Mixtures Containing Cationic Chitosan and Nonionic Sorbitan Esters. Biomacromolecules. 2008, 9:2146–2152. PubMed link
  • Fairley N., Hoang B., Allen C. Morphological Control of Poly(ethylene glycol)-block-Poly(caprolactone) Copolymer Aggregates in Aqueous Solution. Biomacromolecules. 2008, 9:2283–2291. PubMed link
  • Grant J., Lee H., Lim Soo P., Piquette-Miller M., Allen C. Influence of Molecular Organization on Drug Release for an Injectable Polymer-Lipid Blend. International Journal of Pharmaceutics. 2008, 360:83–90. PubMed link
  • Huynh L., Grant J., Leroux J.C., Delmas P., Allen C. Predicting the Solubility of the Anti-Cancer Agent Docetaxel and Small Molecule Excipients using Computational Methods.Pharmaceutical Research. 2008, 25:147-157. PubMed link
  • Vassileva V., Allen C., Piquette-Miller M. Effects of Sustained and Intermittent Paclitaxel Therapy on Tumor Repopulation in Ovarian Cancer. Molecular Cancer Therapeutics.2008, 7:630-637. PubMed link
  • Liu J., Zahedi P., Zeng F., Allen C. Nano-sized Assemblies of a PEG-Docetaxel Conjugate as a Delivery Strategy for Docetaxel. Journal of Pharmaceutical Science. 2008, 97:3274-3290. PubMed link
  • Lim Soo P., Grant J., Cho J., Ho E.A., Piquette-Miller M., Allen C. Drug Release Mechanism of Paclitaxel from a Chitosan-Lipid Implant System: Effect of Swelling, Degradation and Morphology. European Journal of Pharmaceutics and Biopharmaceutics.2008, 69:149-157. PubMed link


  • Rossi J., Khalid M.N., Delmas P., Allen C., Giasson S., Leroux J.C. Long-Circulating Poly(ethylene glycol)-Coated Emulsions Target Solid Tumors. European Journal of Pharmaceutics and Biopharmaceutics. 2007, 67:329-339. PubMed link
  • Vassileva V., Grant J., De Souza R., Allen C., Piquette-Miller M. Novel Biocompatible Intraperitoneal Drug Delivery System Increases Tolerability and Therapeutic Efficacy of Paclitaxel in a Human Ovarian Cancer Xenograft Model. Cancer Chemotherapy and Pharmacology. 2007, 60:907-914. PubMed link
  • Li B., Li F., Allen C., Wilson B. Diblock Copolymer Micelles Deliver Hydrophobic Protoporphyrin IX for Photodynamic Therapy. Photochemistry and Photobiology. 2007, 83:1505-1512. PubMed link
  • Lee H., Hu M., Reilly R.M., Allen C. Apoptotic EGF-Conjugated Block Copolymer Micelles as Nanotechnology Platform for Targeted Combination Therapy. Molecular Pharmaceutics. 20074:769-781. PubMed link
  • Ho E., Allen C., Piquette-Miller E. Novel Drug Delivery Strategies for the Treatment of Ovarian Cancer. Expert Review of Obstetrics & Gynecology. 2007, 2:587-93. Paper link
  • Dos Santos N., Allen C., Doppen A.M., Anantha M., Cox K.A., Gallagher R.C., Karlsson G., Edwards K., Kenner G., Samuels L., Webb M.S., Bally M.B. Influence of Poly(ethylene glycol) Grafting Density and Polymer Length on Liposomes: Relating Plasma Circulation Lifetimes to Protein Binding. Biochimica et Biophysica Acta – Biomembranes. 2007, 6:1367-1377. PubMed link
  • Liu J., Zeng F., Allen C. In Vivo Fate of Unimers and Micelles of a Poly (ethylene glycol)-block-Poly(caprolactone) Copolymer in Mice Following Intravenous Administration.European Journal of Pharmaceutics and Biopharmaceutics. 2007, 65:309-319. PubMed link
  • Zheng J., Liu J., Dunne M., Jaffray D.A., Allen C. In Vivo Performance of a Liposomal Vascular Contrast Agent for CT and MR-Based Image Guidance Applications. Pharmaceutical Research. 2007, 24:1193-1201. PubMed link
  • Grant J., Tomba J.P., Lee H., Allen C. Relationship Between Composition and Properties for Stable Chitosan Films Containing Lipid Microdomains. Journal of Applied Polymer Science. 2007, 103:3453-3460. Paper link
  • Ho E., Lim Soo P., Allen C., Piquette-Miller M. Impact of Intraperitoneal Sustained Delivery on the Expression of P-Glycoprotein in Ovarian Tumors. Journal of Controlled Release. 2007, 117:20-27. PubMed link


  • Liu J., Lee H., Allen C. Formulation of Drugs in Block Copolymer Micelles: Drug Loading and Release. Current Pharmaceutical Design. 2006, 12:4685-4701. PubMed link
  • Cho J., Grant J., Piquette-Miller M., Allen C. Synthesis and Physicochemical and Dynamic Mechanical Properties of a Water-Soluble Chitosan Derivative as a Biomaterial.Biomacromolecules. 2006, 7:2845-2855. PubMed link
  • Zeng F., Allen C. Synthesis of Carboxy-Functionalized Heterobifunctional Poly(ethylene glycol) by a Thiol-Anionic Polymerization Method. Macromolecules. 2006, 39:6391-6398. Paper link
  • Zeng F., Lee H., Allen C. Epidermal Growth Factor-Conjugated Poly(ethylene glycol)-block-Poly(delta-valerolactone) Copolymer Micelles for Targeted Delivery of Chemotherapeutics. Bioconjugate Chemistry. 2006, 17:399-409. PubMed link
  • Grant J., Cho J., Allen C. Self-Assembly and Physicochemical and Rheological Properties of a Polysaccharide-Surfactant System Formed From the Cationic Biopolymer Chitosan and Non-Ionic Sorbitan Esters. Langmuir. 2006, 22:4327-4335. PubMed link
  • Liu J., Lee H., Huesca M., Young A., Allen C. Liposome Formulation of a Novel Hydrophobic Aryl-Imidazole Compound for Anti-cancer Therapy. Cancer Chemotherapy and Pharmacology. 2006, 58:306-318. PubMed link
  • Zheng J., Perkins G., Kirilova A., Allen C., Jaffray D.A. Multimodal Contrast Agent for Combined Computed Tomography and Magnetic Resonance Imaging Applications.Investigative Radiology. 2006 41:339-348. PubMed link


  • Lee H., Zeng F., Dunne M., Allen C. Methoxy Poly(ethylene glycol)- block -Poly(valerolactone) Copolymer Micelles for Formulation of Hydrophobic Drugs.Biomacromolecules. 2005, 6:3119-3128. PubMed link
  • Perkins G., Zheng J., Brock K., Allen C., Jaffray D.A. Nanoengineered Multimodal Contrast Agent for Medical Image Guidance. Proceedings of SPIE. 2005, 5746:31-39. Paper link
  • Zeng F., Lee H., Chidiac M., Allen C. Synthesis and Characterization of Six-Arm Star Poly(d-valerolactone)-block-Methoxy Poly(ethylene glycol) Copolymers.Biomacromolecules. 2005, 6:2140-2149. PubMed link
  • Ho E. A., Vassileva V., Allen C., Piquette-Miler M. In Vitro and In Vivo Characterization of a Novel Biocompatible Polymer-Lipid Implant System Containing Paclitaxel. Journal of Controlled Release. 2005, 104:181-191. PubMed link
  • Grant J., Blicker M., Piquette-Miller M., Allen C. Hybrid Films from Blends of Chitosan and Egg Phosphatidylcholine for Localized Delivery of Paclitaxel. Journal of Pharmaceutical Sciences. 2005 94:1512-27. PubMed link
  • Liu J., Zeng F., Allen C. Influence of Serum Protein on Polycarbonate- Based Copolymer Micelles as a Delivery System for a Hydrophobic Anti-cancer Agent. Journal of Controlled Release. 2005, 103:481-497. PubMed link


  • Zhang H., Oh M., Allen C. Kumacheva E. Monodisperse Chitosan Nanoparticles for Mucosal Drug Delivery. Biomacromolecules. 2004, 5:2461-2468. PubMed link
  • Zeng F., Liu J., Allen C. Synthesis and Characterization of Biodegradable PEG-block-poly(5-benzyloxy-trimethylene carbonate) Copolymers for Drug Delivery.Biomacromolecules. 2004, 5:1810-1817. PubMed link
  • Buck S., Pennefather P.S., Xue H.Y., Grant J., Cheng Y.L., Allen C. Engineering Lipobeads: Properties of the Hydrogel Core and the Lipid Bilayer Shell.Biomacromolecules. 2004, 5:2230-2237. PubMed link
  • Liu J., Xiao Y., Allen C. Polymer-Drug Compatibility: A Guide to the Development of Delivery Systems for the Anti-Cancer Agent, Ellipticine. Journal of Pharmaceutical Sciences. 2004, 93:132-143. PubMed link
  • Dos Santos N., Cox K.A., McKenzie C.A., van Baarda F., Gallagher R.C., Karlsson G., Edwards K., Mayer L.D., Allen C., Bally M.B. pH Gradient Loading of Anthracyclines into Cholesterol-free Liposomes: Enhancing Drug Loading Rates through Use of Ethanol.Biochimica et Biophysica Acta – Biomembranes. 2004, 1661:47-60. PubMed link

2003 and Earlier

  • Allen C. The Merging Fields of Polymer and Lipid-Based Drug Delivery. Journal of Liposome Research. 2003, 13:11-12. Paper link
  • Allen C., Dos Santos N., Gallagher R., Chiu G.N.C., Shu Y., Li W.M., Johnstone S.A., Janoff A.S., Mayer L.D., Webb M.S., Bally M.B. Controlling the Physical Behavior and Biological Performance of Liposome Formulations Through Use of Surface Grafted Poly(ethylene Glycol. Bioscience Reports. 2002, 22:225-250. PubMed link
  • Allen C., Maysinger D., Eisenberg A. Polycaprolactone-b-Poly(ethylene oxide) Copolymer Micelles as a Delivery Vehicle for Dihydrotestosterone. Journal of Controlled Release. 2000, 63:275-286. PubMed link
  • Allen C., Eisenberg A., Mrsic J., Maysinger D. PCL-b-PEO Micelles as a Delivery Vehicle for FK506: Assessment of a Functional Recovery of Crushed Peripheral Nerve. Drug Delivery. 2000, 7:139-145. PubMed link
  • Allen C., Yu Y., Eisenberg A., Maysinger D. Cellular Internalization of PCL20-b-PEO44 Block Copolymer Micelles.  Biochimica et Biophysica Acta – Biomembranes. 1999, 1421:32-38. ScienceDirect link
  • Allen C., Maysinger D., Eisenberg A. Nano-Engineering Block Copolymer Aggregates for Drug Delivery. Colloids and Surfaces B: Biointerfaces. 1999, 16:3-27. ScienceDirect link
  • Allen C., Eisenberg A., Maysinger D. Copolymer Drug Carriers: Conjugates, Micelles and Microspheres. S.T.P. Pharma Sciences. 1999, 9:139-151. Paper link
  • Allen C., Yu Y., Maysinger D., Eisenberg A. Polycaprolactone-b-poly(ethylene oxide) Block Copolymer Micelles as a Novel Drug Delivery Vehicle for Neurotrophic Agents FK506 and L-685,818. Bioconjugate Chemistry. 1998, 9:564-573. PubMed link
  • Zhao J., Allen C., Eisenberg A. Partitioning of Pyrene between “Crew-Cut” Block Copolymer Micelles and H2O/DMF Solvent Mixtures. Macromolecules. 1998, 30:7143-7150. Paper link